The device went off around midday as the suicide bomber tried to enter the library at Federal College of Education, Kontagora, student Samson Kazah told Reuters. He said he saw at least one other body and the explosion wounded one of his friends.
“The female suicide bomber blew herself up before reaching her target,” said a police spokesman.
Casualty figures are unclear, but lecturer Andrew Randa told the BBC he had seen four bodies.
The attack comes two daysafter another suicide bomber killed at least 47 students at the assembly ground of Government Science Secondary School (GSS) in Potiskum in Yobe State.
Mr Randa said he heard a deafening blast and then there was pandemonium as people ran away from the scene.
Soldiers rushed to the college and sealed off the area, he said.
Niger State police spokesman Ibrahim Gambari confirmed the blast by telephone from Minna, saying commanders were awaiting further details from officers on the ground.
“We have dispatched our teams from here,” he told AFP.
No one has claimed responsibility for the attack but all eyes are on Islamist militant group Boko Haram.