Vice President Yemi Osinbajo and his wife, Dolapo, are expected to vote at the Victoria Garden City (VGC) in Lagos on Saturday.
Voting opened at 8 a.m. President Muhammadu Buhari and his wife, Aisha, have cast their votes in Daura, Katsina State.
Prof. Osinbajo arrived in Lagos for the exercise following the close of campaigns at midnight on Thursday.
Osinbajo, an indigene of Ikenne, Ogun State, lived and worked in Lagos before he was elected vice president in 2015.
He worked as a law professor at the University of Lagos (UNILAG) for many years.
From 1999-2007, Osinbajo was attorney-general and commissioner of justice in Lagos State.